Harmen J Bussemaker1
Illustrating the analogy between Ohm's Law and 'Omes Law'
Sat Aug 25, 2007 23:22
 
Illustrating the analogy between Ohm's Law and 'Omes Law'.
http://www.nature.com/msb/journal/v2/n1/fig_tab/msb4100055_F1.html


Illustrating the analogy between Ohm's Law and 'Omes Law'. The work of Nguyen and D'haeseleer extends a class of linear models for gene expression regulation that has a very direct and useful analogy to basic electricity theory. (A) In an electrical circuit, Ohm's Law, I=GV, describes the linear relation that exists between the current (I) through a resistor and the voltage (V) that drives it, the constant of proportionality being the conductivity (G) of the resistor. We use a color-coding scheme where a scale from white (G=0) to dark brown (G>0) represents conductivity, green (I<0) to red (i>0) via black (I=0) represents current, and blue (V<0) to yellow (v>0) via black (V=0) represents voltage. (B) In a gene regulatory network, changes in 'hidden' post-translational TF activity play the role of the voltage, while the resulting changes in mRNA expression level play that of the current. For any given TF, the regulatory strength of DNA binding sites in the upstream region, or 'conductivity', varies greatly between genes. The change in mRNA expression for a given gene is a weighted combination of the changes in activity of the TFs that bind to its upstream region. In the example shown, gene X is only controlled by factor A, while gene Y is controlled by both factor A and factor B. Therefore, while gene X is upregulated (red) in response to the increase in the activity of factor A (yellow), the decrease in the activity of factor B (blue) causes the net change in expression of gene Y to be zero (black). The many-to-many relationship between TF activities and mRNA expression levels can be summarized in the form of a linear matrix equation ('Omes Law'). (C) Schematic depiction of the iterative procedure used by Nguyen and D'heaseleer to simultaneously infer a matrix of condition-specific TF activity changes (blue/yellow) and a matrix of gene-specific motif strengths (white/brown), which together optimally explain the observed mRNA expression changes (green/red).

======================

Ohm's Law Calculations
http://www.csgnetwork.com/ohmslaw.html

9-11 Count Up Calculator...OHM'S LAW CALCULATIONS
It's been 2174 days since the 9-11 tragedy!
http://www.csgnetwork.com/911countupcalc.html

This calculator timer requires the use of Javascript enabled and capable browsers. This is a reminder of the terrible tragedy of 9/11/2001. God Bless those that gave their lives. Let us never forget the terrorists that hate America!

The attacks began with the hijacking of four commercial airliners departing from East Coast airports, fueled for flights to California. With jet fuel capacities of nearly 24,000 U.S. gallons (91,000 liters) or 144,000 pounds (65,455 kilograms), each aircraft effectively became an incendiary guided missile.

American Airlines Flight 11, a Boeing 767-223, wide-body aircraft crashed into the north side of the North Tower of the World Trade Center (WTC) at 8:46:30 a.m. local time (which was Eastern Daylight Time, or 12:46:30 UTC).

United Airlines Flight 175, a Boeing 767-222, crashed into the South Tower at 9:02:59 a.m. local time (13:02:59 UTC), an event covered live by television broadcasters from around the world who had their cameras trained on the buildings after the earlier crash.

American Airlines Flight 77, a Boeing 757-223, crashed into the Pentagon at 9:37:46 a.m. local time (13:37:46 UTC).

United Airlines Flight 93, a Boeing 757-222, crashed in a field in southwest Pennsylvania just outside of Shanksville, about 150 miles (240 km) northwest of Washington, D.C., at 10:03:11 a.m. local time (14:03:11 UTC), with parts and debris found up to eight miles away. The crash in Pennsylvania is believed to have resulted from the hijackers either deliberately crashing the aircraft or losing control of it as they fought with the passengers.

No one onboard any of the hijacked aircraft survived.

The fatalities were in the thousands, with 2,973 people killed, including 246 on the four planes, 2,602 in New York City in the towers and on the ground, and 125 at the Pentagon. Among the fatalities were 343 New York City Fire Department firefighters, 23 New York City Police Department officers, and 37 Port Authority police officers. An additional 24 people remain listed as missing in the attack on the World Trade Center to this day.


Let Us Never Forget 9-11
http://www.csgnetwork.com/911countupcalc.html

Subroutines And Snippets Source Code
For Converters and Calculators
http://www.csgnetwork.com/sssconverters.html

Lottery Number Selectors, Converters and Calculators
http://www.csgnetwork.com/lotterycalcs.html


Main Page - Monday, 08/27/07

Message Board by American Patriot Friends Network [APFN]

APFN MESSAGEBOARD ARCHIVES

messageboard.gif (4314 bytes)